Epileptic seizures arise when the activity of the brain gets out of control. A large research team at CNCR has investigated how the brain controls its activity and identified a new molecular pathway involving the synaptic protein Munc18-1 that helps the brain to slow down when activity gets too high. The study appeared in EMBO Journal.
FGA PhD-student Cijsouw and PI Toonen present a new mouse model, expressing a fluorescently tagged version of a protein, Munc18-1. This protein is essential for synaptic transmission. Their findings are published in the march issue of the JCB.