Publications

Brouwer, I. et al. Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes. Nat. Commun. 6, 8387 (2015).

Beunders, G. et al. Two male adults with pathogenic AUTS2 variants, including a two-base pair deletion, further delineate the AUTS2 syndrome. Eur. J. Hum. Genet. 23, 803–807 (2015).

Geerts, C. J. et al. Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates. Brain Struct. Funct. 220, 1971–82 (2015).

Giniatullina, A. et al. Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences. Neuroscience 300, 518–538 (2015).

Tan-Sindhunata, M. B. et al. Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence. Eur. J. Hum. Genet. 23, 1151–7 (2015).

Geerts, C. J., Jacobsen, L., Van De Bospoort, R., Verhage, M. & Groffen, A. J. A. Tomosyn interacts with the SUMO E3 ligase PIASγ. PLoS One 9, (2014).

Li, J. et al. DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. Diabetologia 57, 2173–82 (2014).

Beunders, G. et al. Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus. Am. J. Hum. Genet. 92, 210–20 (2013).

Groffen, A. J. A., Klapwijk, T., van Rootselaar, A.-F., Groen, J. L. & Tijssen, M. A. J. Genetic and phenotypic heterogeneity in sporadic and familial forms of paroxysmal dyskinesia. J. Neurol. 260, 93–9 (2013).

Labonté, D. et al. TRIM3 Regulates the Motility of the Kinesin Motor Protein KIF21B. PLoS One 8, e75603 (2013).

Pinheiro, P. S. et al. Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release. J. Neurosci. 33, 16459–16470 (2013).

Ramalingam, L. et al. Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity. Diabetes 61, 2424–32 (2012).

Van Strien, T. W. et al. Paroxysmal kinesigenic dyskinesia: Cortical or non-cortical origin. Park. Relat. Disord. 4–7 (2012).

Dudok, J. J., Groffen, A. J. A., Toonen, R. F. T. & Verhage, M. Deletion of Munc18-1 in 5-HT Neurons Results in Rapid Degeneration of the 5-HT System and Early Postnatal Lethality. PLoS One 6, e28137 (2011).

Walter, A. M., Groffen, A. J., Sørensen, J. B. & Verhage, M. Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats? Trends Neurosci. 34, 487–97 (2011).

Groffen, A. J. et al. Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science 327, 1614–8 (2010).

Dudok, J. J., Groffen, A. J. A., Witter, M. P., Voorn, P. & Verhage, M. Chronic activation of the 5-HT receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain Res. 1302, 1–9 (2009).

Friedrich, R. et al. DOC2B acts as a calcium switch and enhances vesicle fusion. J. Neurosci. 28, 6794–6806 (2008).

Groffen, A. J. A. & Verhage, M. Molecular Mechanisms of Exocytosis. Mol. Mech. Exocytisis (Springer New York, 2007). doi:10.1007/978-0-387-39961-4

Groffen, A. J. A., Friedrich, R., Brian, E. C., Ashery, U. & Verhage, M. DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties. J. Neurochem. 97, 818–833 (2006).

Groffen, A. J. A., Jacobsen, L., Schut, D. & Verhage, M. Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain. J. Neurochem. 92, 554–568 (2005).

Groffen, A. J. A. et al. Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane. J. Biol. Chem. 279, 23740–7 (2004).

Kolk, S. M. et al. Differential distribution and regulation of expression of synaptosomal-associated protein of 25 kDa isoforms in the Xenopus pituitary gland and brain. Neuroscience 128, 531–543 (2004).

Yard, B. A. et al. Decreased Glomerular Expression of Agrin in Diabetic Nephropathy and Podocytes, Cultured in High Glucose Medium. Nephron Exp. Nephrol. 9, 214–222 (2001).

Groffen, A. J., Veerkamp, J. H., Monnens, L. A. & van den Heuvel, L. P. Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane. Nephrol. Dial. Transplant 14, 2119–29 (1999).

Groffen, A.J. et al. Primary structure and high expression of human agrin in basement membranes of adult lung and kidney. Eur. J. Biochem. 254, 123–8 (1998).

Groffen, A J. et al. Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. J. Histochem. Cytochem. 46, 19–27 (1998).

Raats, C. J. et al. Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies. J. Biol. Chem. 273, 17832–8 (1998).

Groffen, A. J. et al. Evidence for the existence of multiple heparan sulfate proteoglycans in the human glomerular basement membrane and mesangial matrix. Eur. J. Biochem. 247, 175–82 (1997).

Groffen, A. J. et al. Expression and characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells. Eur. J. Biochem. 241, 827–34 (1996).

Martens, J. W. et al. Characterization of baculovirus insecticides expressing tailored Bacillus thuringiensis CryIA crystal proteins. J. Invertebr. Pathol. 66, 249–57 (1995).

Nolling, J., Groffen, A. & de Vos, W. M. F1 and F3, two novel virulent, archaeal phages infecting different thermophilic strains of the genus Methanobacterium. J. Gen. Microbiol. 139, 2511–2516 (1993).