Publications

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Key publications of the department of the last 10 years:

1: Emperador Melero J, Nadadhur AG, Schut D, Weering JV, Heine VM, Toonen RF,Verhage M. (2017) Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons. Stem Cell Reports 2017, 2213-6711(17)30035-8.

2: de Jong AP, Meijer M, Saarloos I, Cornelisse LN, Toonen RF, Sørensen JB, Verhage M. (2016) Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity. Proc Natl Acad Sci U S A 3;113(18):5095-100.

3: Schmitz SK, King C, Kortleven C, Huson V, Kroon T, Kevenaar JT, Schut D, Saarloos I, Hoetjes JP, de Wit H, Stiedl O, Spijker S, Li KW, Mansvelder HD, Smit AB, Cornelisse LN, Verhage M, Toonen RF. (2016) Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1. EMBO J. 35(11):1236-50.

4: Schotten S, Meijer M, Walter AM, Huson V, Mamer L, Kalogreades L, ter Veer M, Ruiter M, Brose N, Rosenmund C, Sørensen JB, Verhage M, Cornelisse LN. (2016) Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate. Elife 4:e05531.

5: Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH,Verhage M, Toonen RF. (2015) CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. Elife 10.7554

6: Walter AM, Kurps J, de Wit H, Schöning S, Toft-Bertelsen TL, Lauks J, Ziomkiewicz I, Weiss AN, Schulz A, Fischer von Mollard G, Verhage M, Sørensen JB. (2014) The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J. 33(15):1681-97.

7: Aarts E, Verhage M, Veenvliet JV, Dolan CV, van der Sluis S. (2014) A solution to dependency: using multilevel analysis to accommodate nested data. Nature Neurosci. 17(4):491-6.

8: Cijsouw T, Weber JP, Broeke JH, Broek JA, Schut D, Kroon T, Saarloos I, Verhage M, Toonen RF. (2014) Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol. 204(5):759-75.

9: Genc O, Kochubey O, Toonen RF, Verhage M, Schneggenburger R. (2014) Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release. Elife 3:e01715.

10: Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. (2013) Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron 79(5):970-86.

11: Ripke S, [….], Posthuma D, [….], Verhage M, [….], Sullivan PF. (2013) Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genet. 45(10):1150-9.

12: Nair R, Lauks J, Jung S, Cooke NE, de Wit H, Brose N, Kilimann MW, Verhage M, Rhee J. (2013) Neurobeachin regulates neurotransmitter receptor trafficking to synapses. J Cell Biol. 200(1):61-80.

13: van de Bospoort R, Farina M, Schmitz SK, de Jong A, de Wit H, Verhage M, Toonen RF. (2012) Munc13 controls the location and efficiency of dense-core vesicle release in neurons. J Cell Biol. 199(6):883-91.

14: Heutink P, Verhage M. (2012) Neurodegeneration: new road leads back to the synapse. Neuron 75(6):935-8.

15: van der Sluis S, Posthuma D, Nivard MG, Verhage M, Dolan CV. (2013) Power in GWAS:lifting the curse of the clinical cut-off. Mol Psychiatry 18(1):2-3.

16: de Jong AP, Schmitz SK, Toonen RF, Verhage M. (2012) Dendritic position is a major determinant of presynaptic strength. J Cell Biol. 197(2):327-37.

17: Meijer M, Burkhardt P, de Wit H, Toonen RF, Fasshauer D, Verhage M. (2012) Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. EMBO J. 31(9):2156-68.

18: Toonen RF, Verhage M. (2011) Crashpilot underachieves due to acetylation at the nerve terminal. Neuron 72(5):679-81.

19: Lips ES, Cornelisse LN, Toonen RF, Min JL, Hultman CM; International Schizophrenia Consortium., Holmans PA, O’Donovan MC, Purcell SM, Smit AB, Verhage M, Sullivan PF, Visscher PM, Posthuma D. (2012) Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry 17(10):996-1006.

20: Mohrmann R, de Wit H, Verhage M, Neher E, Sørensen JB. (2010) Fast vesicle fusion in living cells requires at least three SNARE complexes. Science 330(6003):502-5.

21: Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O’Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF (2011) Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 16(1):2-4.

22: Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M. (2010) Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science 327(5973):1614-8.

23: Verhage M. (2009) Organelle docking: R-SNAREs are late. Proc Natl Acad Sci U S A. 106(47):19745-6.

24: de Wit H, Walter AM, Milosevic I, Gulyás-Kovács A, Riedel D, Sørensen JB, Verhage M. (2010) Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell 138(5):935-46.

25: Bochdanovits Z, Verhage M, Smit AB, de Geus EJ, Posthuma D, Boomsma DI, Penninx BW, Hoogendijk WJ, Heutink P. (2009) Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder. Mol Psychiatry 14(7):650-2.

26: Verhage M, van Meer G. (2009) Synaptobrevin, sphingolipids, and secretion: lube ‘n’ go at the synapse. Neuron 62(5):603-5.

27: Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, Macintyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nöthen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van Dyck R, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW. (2009) Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 14(4):359-75.

28: Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321(5895):1507-10.

29: Wierda KD, Toonen RF, de Wit H, Brussaard AB, Verhage M. (2007) Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity. Neuron 54(2):275-90.