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  4. 2018

HIV-drug corrects cholesterol metabolism in Alzheimer’s disease

Dr. Rik van der Kant (CNCR-FGA) and colleagues report that accumulation of cholesterol in Alzheimer’s disease neurons drives early Tau- and Amyloid pathology, and can be reversed by cholesterol-targeting drugs. Published in Cell Stem Cell.

Clinic day on 13 Oct marks successful start to new STXBP1 study

On Saturday the 13th of October the first group of STXBP1-E families came to the VUmc to participate in the new study on STXBP1-Encephalopathy.

New study on pool sizes published in EMBO J.

Claudia Persoon (CNCR-FGA) & the DCV team published a study on how many secretory vesicles are found in different CNS neurons (this paper is about vesicle pools, not swimming pools!) and how many vesicles fuse upon stimulation. The paper is featured on the cover of EMBO J. this month.

CNCR and VUmc together host the first STXBP1-E Patient Clinic

On Oct. 13, the 1st STXBP1 Patient Clinic Day will take place at VUmc in Amsterdam. The day is part of our studies on STXBP1-Encephalopathy (STXBP1-E) in a collaboration between FGA-CNCR, Clinical Genetics and VU spin-off company NBT Analytics.

New study on Golgi function & secretion in Nature Comm.

PhD student Javier Emperador Melero (CNCR-FGA) published his study on the role of retrograde trafficking, Golgi export and regulated secretion in Nature Communications this month. Javier is now on his way to his new job at Harvard University.

Kevin Batenburg (FGA) receives poster prize at DNM 2018

At the Dutch Neuroscience Meeting (DNM), PhD student Kevin Batenburg won the poster prize for his poster on the development of a human three-dimensional screening platform of tau pathology.

PhD student Kevin Batenburg (FGA) wins poster prize

At the 2nd EuroTau meeting in Lille, France, Kevin won the poster prize for his poster on the development of a human three-dimensional screening platform of tau pathology.

STXBP1-study by Kovačević & colleagues published in Brain

A team of FGA/CNCR researchers together with US/Swedish partners (SUN project) and VU spin-off Sylics characterize mechanisms underlying the seizures and cognitive deficits in STXBP1-encephalopathy and present several new animal models.
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