Epileptic seizures arise when the activity of the brain gets out of control. A large research team at CNCR has investigated how the brain controls its activity and identified a new molecular pathway involving the synaptic protein Munc18-1 that helps the brain to slow down when activity gets too high. The study appeared in EMBO Journal.
A new study published on 18 September 2015 in Nature Communications provides new insight in the mechanism of cellular secretion. The results emerge from a collaborative study by the groups of Sander Groffen (Molecular mechanisms of secretion) and Gijs Wuite (Physics of Living Systems).
FGA PhD-student Cijsouw and PI Toonen present a new mouse model, expressing a fluorescently tagged version of a protein, Munc18-1. This protein is essential for synaptic transmission. Their findings are published in the march issue of the JCB.
The CNCR team of Sander Groffen and Matthijs Verhage discovered that the Doc2b gene is a Ca2+-sensor responsible for triggering spontaneous release events. Their findings are published as a full length article in the accelerated online version of Science on Febr 11th, 2010.