Rhodé van Westen (CNCR-FGA) and colleagues identify Synaptotagmin-1 and Synaptotagmin-7 as redundant calcium sensors for neuromodulator secretion from dense core vesicles in mammalian neurons. This study is published in PNAS on April 28th.

CNCR/FGA is seeking applications for an Assistant Professor in RNA Biology and application in neuroscience, who will develop an independent research program to explore new directions in translation regulation, RNA stability or –transport.

The EM core facility at the VU campus has applied their long-standing experience of monolayer ultrastructural analysis to a different field, the analysis of mircoogranisms such as bacteria.

De “outreach” activiteiten van het team Molecular Neurodegeneration van Wiep Scheper zijn beloond door de KNAW met de toekenning van een award van het pilotfonds ‘Wetenschapscommunicatie door wetenschappers: Gewaardeerd’!

With this take-off grant Claudia Persoon will investigate the commercial potential of the human neuron cell models and imaging techniques developed at Amsterdam UMC and VU University in search of new treatments for brain disorders.

a young patient who carries a SYT1 mutation is the first to receive a mechanism-based treatment with the prescription of bumetanide, aiming to reverse excitation/inhibition disturbance

A collaboration between the group of Rik van der Kant (FGA) and Martin Giera (LUMC) has been selected for funding by the Chan Zuckerberg Initiative Neurodegeneration Network. In the first phase of their project, the researchers will receive $150.000 to establish an atlas of the human lipidome in iPSC-derived neurons, astrocytes and microglia in controls and subjects with mutations associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

Claudia Persoon and Matthijs Verhage developed new preclinical screening assays using functional, mature human neurons and CRISPR-Cas9 technology, to promote identification of promising treatment strategies for brain disorders.

A position paper by Verhage & Sorensen published in Neuron on June 19 proposes to unify syndromes caused by mutations in eight core components of the synaptic secretion machinery, based on common etiology and mechanism

Alzheimer Nederland awarded a €65 000 fellowship to Lill Eva Johansen for research on the effect of Abca7 mutations associated with Alzheimer’s disease. The work will be performed in human brain cells derived from stem cells that are gene edited using CRISPR technology.