Secretory vesicle trafficking and recycling
We study the transport, docking, fusion and retrieval of two type secretory vesicles: small translucent neurotransmitter vesicles in pre-synapse of neurons and neuropeptide-containing, large dense-core vesicles in neurons and neuro-endocrine cells. The focus lies on the interactions between these secretory vesicles and the cytoskeleton as well as protein/lipid interactions in genetic model systems for disease.