A team of FGA/CNCR researchers together with US/Swedish partners (SUN project) and VU spin-off Sylics characterize mechanisms underlying the seizures and cognitive deficits in STXBP1-encephalopathy and present several new animal models.
At the annual meeting of the graduate school Neurosciences Amsterdam and Rotterdam (ONWAR) CNCR members Marieke van Ziel, Vincent Huson, Marinka Brouwer, Claudia Persoon and Mariana Raimundo Pinto de Matos won the Blitz presentation and oral presentation prices.
The SYNGO project, a joint initiative of CNCR (MCN, FGA), The Broad Institute/Stanley Center in Cambridge, USA and the GO-consortium, announced reaching their phase II targets towards the evidence-based annotation of synaptic genes.
A study by Enqi He (CNCR-FGA) published in Nature Communications demonstrates how synaptic vesicles remain in a high-energy (‘primed’) state, ready to be released. Two proteins, Munc13-1 and Munc18-1, stabilize the primed state by preventing de-priming and hereby support high frequency synaptic transmission.
Margherita Farina will defend her thesis ‘Trafficking and secretion of neuropeptides in mouse hippocampal neurons’. Related to this event, the German expert on BDNF signalling, Prof. V. Lessmann, will present a lecture “Postsynaptic BDNF secretion and action in spike timing-dependent LTP“ on Wed, June28th 3PM @W&N F123